As I have previously written, smoking tobacco products is probably one of the most destructive things people can do to themselves. Tobacco dependence remains the primary preventable cause of death in the United States. Addiction to tobacco and nicotine is a more powerful addiction than opioids and narcotics. That being said, it is fair to say that most smokers want to quit smoking but can’t. While some smokers are able to abruptly stop smoking (“cold turkey”), most smokers cannot suddenly stop. In order to quit, most smokers require a combination of pharmacologic therapy and counseling. Today, I would like to discuss pharmacologic treatment for smoking cessation.
Let’s start with nicotine replacement therapies (NRTs). Nicotine undergoes